People, every show

Carlos Araya

Founder, Tapanti.org. On 1 show, 2 appearances. The Shows tab opens the full record on each.

founderexecutivescientisttapanti.org ↗

Carlos L. Araya is an entrepreneur and scientist who co-founded and served as CEO of Jungla Inc., a biotechnology startup that developed computational modeling engines to interpret genetic variants. Jungla was acquired by Invitae Corporation in 2019, integrating its clinical variant modeling technology into genetic diagnostics.

What they said6 Shows1

Everything Carlos Araya said on any show that made the record, most notable first. Each card names its show and opens the statement there.

a16z Assertion Supported

Interpreting novel genetic variants costs 100x to 1000x more than sequencing

“And interpreting each one of those under the current clinical practices costs 50 to a hundred dollars. So we're talking about a hundred to thousand-fold increase in the cost of interpretation relative to the cost of data acquisition.”

Carlos Araya Jan 2, 2019 ▶ 2:59 a16z Podcast | Revisiting the Gene

a16z Assertion Supported

Only 0.6% of disease-associated gene mutations have clinical interpretations

“If we look across all of the disease-associated genes that we know today, we only have clinical interpretations for roughly . Six percent of the possible mutations in them.”

Carlos Araya Jan 2, 2019 ▶ 3:52 a16z Podcast | Revisiting the Gene

a16z Assertion Contradicted

Araya: Cancer gene tests find 95 unknown mutations per known mutation

“Those tests will basically find 95 mutations that they have absolutely no clue of what the effects of those mutations are in these important cancer-associated genes per each mutation that is known to cause disease.”

Carlos Araya Jan 2, 2019 ▶ 21:04 a16z Podcast | When Will Genomics Live Up to the Hype?

a16z Assertion Not checkable as stated

Araya: DNA sequencing is the second-fastest advancing technology in history

“We've done a pretty good job at being able to acquire sequence information. That's, you know, some of the fastest advances in technology in the history of mankind. I'm told it's actually only beat by one other technology, which is the sort of the clarity of gl…”

Carlos Araya Jan 2, 2019 ▶ 6:43 a16z Podcast | When Will Genomics Live Up to the Hype?

a16z Assertion Not checkable as stated

Araya: Existing genomic maps lack the functional data needed for applications

“Unfortunately the maps that we have today are really maps of function that just say where things that are, things like genes, biomolecules, where they are encoded in the genome, but it says really nothing about how they function and which parts of the genes do…”

Carlos Araya Jan 2, 2019 ▶ 7:27 a16z Podcast | When Will Genomics Live Up to the Hype?

a16z Assertion Contradicted

Each sequenced genome contains about 100 novel variants in disease genes

“Although there are three million variants identified, There will be roughly a hundred variants that are novel variants in disease-associated genes.”

Carlos Araya Jan 2, 2019 ▶ 2:48 a16z Podcast | Revisiting the Gene

One line per show, most statements first. The link opens Carlos's full record on that show: the calibration, argument clarity, speaking style and every statement made there.

Show	Role there	Eps	Statements	Record
a16zLEDGER	Founder, Tapanti.org	2	6	50% 2/4	full record on the a16z Podcast →