ESM Two

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Incorporating metagenomic training data eliminated diminishing returns in ESMC protein foundation models
“And then, you know, what we saw basically is, is, is there are no longer diminishing returns to scale. So that's really saying that ESM two was kind of data limited rather than compute limited for ESMC.”
Alex Rives May 27, 2026 ▶ 24:23 🔬 The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

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