Chromatin
topic on 1 show · 3 statements across 1 episodes
3 statements about Chromatin, every show
Belmonte: Short Yamanaka factor pulses alter chromatin while preserving cell identity
“Rather than having the factors for a long time, we just gave a short pulse. What that is doing is altering the chromatin, but for a very short time, it's a small shock, and then the chromatin gets closed and maintains its identity.”
Belmonte: Epigenetic reprogramming rejuvenates mice without altering their underlying DNA
“Just by this small change in the chromatin, we can rejuvenate a mouse.”
Belmonte: Closed chromatin maintains cell youth while open chromatin causes aging
“When the epigenome, when the chromatin is closed, we call this heterochromatin, the cell is young, is healthy. When the chromatin is open, it leads to the increase, the loss of buffer capacity, and therefore, disease and aging.”