Eli Lilly

“This moment, this insulin moment, this is what really turbocharges them and makes them into one of, if not the first kind of leading American and international pharmaceutical company, which it still is to this day, still bigger than Nova Nordisk. Although not …”

“Gross margins are better than software. They run about 84%. Lilly is also a very high margin company, running about 80%. For context, Microsoft has a gross margin of 70% and Google is 56%.”

“The first drug that they genetically engineered And that started this whole revolution was insulin.”

“So Nordisk, rather than building up production facilities around the world, what they decide to do is license it back to basically any interested pharma company. So like Eli Lilly back in the States, other companies in Continental Europe. It's the new, widely …”

“So the new combined company has roughly a billion dollars in insulin revenue and 50%, five zero percent global market share with Eli Lilly just behind at 45% and host at five percent.”

“Eli Lilly develops it into Bayetta, and Bayetta hits the market in 2005. It's FDA approved, and it works. It's not poisonous. It doesn't kill people. And it is the world's first GLP-I analog to come to market.”

“85% of their revenue is dedicated to metabolic disorders. They are the second largest market cap pharma, second only to Eli Lilly.”

“Sanofi today, yeah, the three of those companies are essentially the entire insulin market.”

“The other interesting thing to note about the Eli Lilly license, David, which I thought was really clever, is it's a one-year exclusive license where there's two conditions, and the conditions are a trade. One, Eli Lilly has to report back any advances that th…”

“I think this is going to be like insulin all over again, where there's just going to be a series of product improvements and companies will drive innovation and increase supply. I mean, the demand is so huge out there that Monroe can be a huge hit. Ozempic and…”

“The studies show Manjaro helps you lose more weight and has a very similar mechanism plus another mechanism that together work, but like, most people don't know that.”

“Eli Lilly has publicly claimed that the cost of these discounts and rebates accounted for 75% of the sticker price of insulin.”

“Is they license production and development rights to a large American drug company based in Indiana, Eli Lilly. And they give Eli Lilly a one-year exclusive development license to try and mass produce this substance.”

“Novo's annual global insulin sales, this is Novo, they're still much larger. They're about a hundred million dollars annually. And Nordisk's are about thirty million annually. That makes them the number two and number four producers in the world by market shar…”

“So I think, assuming that Novo stays sort of neck and neck with Eli Lilly as they both keep coming out with better and better versions, that this could be the next Humira, or potentially much bigger than Humira. And I think the defensibility is an open questio…”

“It was approved in the US for diabetes treatment in May, 20, 22, and approval just came recently in November, 20, 23 for official FDA sanctioned weight loss use case under the marketing name Zep bound.”

“In 1999, I think it was, Eli Lilly sold seven hundred million dollars of insulin in America. 1999. By 2017, just two of their products sold 2.6 billion dollars in America.”