CRISPR

“What scientists were able to do is they were able to take this video, the pixels from this video, and using CRISPR can coax a bacterial cell to ingest the information and store it in its DNA. And on the right, what you're seeing Is scientists' ability to retri…”

“And now I think with the advent of things like CRISPR and things that companies like Asimov are doing where they're actually making DNA a design medium. I think it's, we're actually starting to make genetic engineering be an engineer discipline.”

“So as we advance our ability to deliver gene therapy, as we advance our ability to actually very precisely edit the genes, and only the genes that we need to edit, gene therapy will become applicable to a far broader range of diseases, not just limited to thos…”

“On this point, you can't stop technology. You can't suppress it. These things are coming. CRISPR is coming to design your baby someday. Driverless cars are coming.”

“As we move biology more and more into an engineer-based discipline, I think we're going to see more powerful modalities like CRISPR.”

“CRISPR is a concept barely registered just a few years ago, and now it's an indispensable tool for drug discovery, for, actually, for understanding biology, as we've seen the cycles of iteration in biology accelerate.”

“I also think we're going to see a lot of interesting things in the non-therapeutic CRISPR space. So in a therapeutic CRISPR side, there are a bunch of public companies that are going directly after using CRISPR to cure disease. I think it's just the beginning …”

“And now I think with the advent of things like CRISPR and things that companies like Asimov are doing where they're actually making DNA a design medium. I think it's, we're actually starting to make genetic engineering be an engineer discipline, but I think th…”

“Yeah, I think that we want an example of a disease that is very common, and most of the gene therapies are rare, whether they're editing or not, and we want something that's very serious, and certainly HIV falls in that category, So it struck me as a plausibly…”

“Ignoring the fact that if you're in an IVF, PGD clinic anyway. To do your CRISPR editing of your Mendelian disease, you could just do selection for most of these things.”

“So what CRISPR does well, it's often described as editing. It really is damaging, is what it is. It's not really that good at precision editing.”

“Compared to old tools, engineering was cut down from a few months to a matter of weeks or days.”

“Some Cas nucleases are much smaller, come from less immunogenic strains, are more precise, or have new mechanisms altogether.”

“As we continue to mine new metagenomic data of new species, it's not crazy to think that perhaps even CRISPR itself is by no means the final frontier of genome engineering.”

“Instead of just this pair of molecular scissors that everyone talks about, the biggest recent shift in the field is this push towards making CRISPR a search engine platform of the cell.”

“We can even now directly target and edit RNA bases, opening up the entire field of transcriptomic editing.”

“When they're all in a pool, you eliminate all of those artifacts, and all of a sudden you have the ability to measure a genome-wide CRISPR screen, basically, so, 20,000 genes in the genome, all modifying the same cellular background in the same dish with a dif…”

“It's barely been 10 years since the concept of CRISPR was discovered and described in the scientific literature. So we went from the initial discovery of CRISPR as a potential use as a medicine, all the way to an approval in just over 10 years. That is lightni…”

“They're fully investing in the things I thought were very important at the time, which was, you know, these large genetic databases coming online and functional genomics. So he was way ahead in the, in sort of the thinking about CRISPR and like the gene pertur…”