The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 23 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 1 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Sadeghi: Nucleus is the first company to optimize embryos for IQ
“This is the first time a company has partnered with a couple who have optimized their embryos on the basis of intelligence.”
Sadeghi: Patients, not doctors, should use genetic data to select embryos
“We believe that every piece of information from cancer to IQ to schizophrenia belongs very thoughtfully in the hands of the patient, and the patient is the one, not the doctor, that the patient is the one that should pick their embryo.”
Nucleus software analyzes embryo DNA to predict IQ, cancer risk, and traits
“So usually parents have a couple viable embryos, and now they can actually take the raw DNA files of them, upload to Nucleus, and we'll give you analysis on everything from cancers, to IQ, to eye color, to hair color, to schizophrenia risk.”
Sadeghi: Falling IVF and sequencing costs will create genetically optimized children
“And so you're going to see the rapid decrease in cost of IVF combined with the rapid decrease in cost of sequencing A genome. These things are going to converge together to enable this just, this massive, massive new generation of parents having genetically op…”
Sadeghi: Future reproductive genomics platforms will both sequence and edit DNA
“Because eventually, you're not just going to be sequencing and analyzing DNA, You'll also probably be editing it as well.”
Sadeghi: The medical distinction between genetic diseases and traits is arbitrary
“From our perspective as a company, there's really no difference between diseases and traits. It's a false line in the sand that was drawn.”
Sadeghi: Scientific research already links genetics directly to intelligence
“At the frontier of science, we do already have associations with genetics and intelligence, and we really believe in giving these insights to customers.”
Sadeghi: Study shows over 50% of people accept genetic optimization for IQ
“There was actually a really good study that was done asking couples about genetic optimization, which is, you know, what's their perspective on it. And in the study, it said over 50% of people said genetic optimization for something like IQ is fine. And then I…”
Sadeghi: Embryo selection can only shift IQ by a few points
“Embryo selection will always be a relative optimization, right? IQ can explain a couple IQ points, right? Height, you can, you know, explain a couple inches, but principally if you, the most important kind of the ingredients for your embryos comes from mom and…”
Sadeghi: Embryo selection can dramatically reduce Alzheimer's and cancer risks
“You can still dramatically reduce the baby's risk, for example, for something like Alzheimer's, Which is then strongly associated with longevity or breast cancer or coronary artery disease, which are the top killers in the United States today.”
Sadeghi: Genomic sequencing, analysis, and editing will create a trillion-dollar industry
“And when you think about the next 10 years, you know, as I alluded to earlier, sequencing technology is kind of cheaper, analysis is kind of cheaper, understand the genome is going to dramatically increase, and genome editing is going to become much cheaper. A…”
Sadeghi: Genetics alone can never predict IQ due to 50% environmental factor
“You can't. From genetics predicts someone's IQ. And actually what a lot of people don't realize is you will never be able to. And the reason for that is because 50% of intelligence is environmental. The other 50% is genetic.”
Sadeghi predicts a trillion-dollar platform integrating all personal health data
“I think we're in the age where there will be a trillion dollar consumer healthcare business, and that business is going to be integrated in the entirety of someone's health data on the platform.”
Sadeghi: Genome analysis technology will be as transformative as AI
“I think genetic testing technology and analysis technology, genome technology, if you will, It's going to be as powerful as artificial intelligence. Artificial intelligence is ultimately a tool, and it's a tool that's going to, I think, be most consequential i…”
Sadeghi: Nucleus IQ benchmarks against genetic cohorts, rather than predicting IQ
“Nucleus IQ, the function of it is not to predict your IQ score. The way it works is it basically tells you people with similar genetics to you, how they tend to score on an IQ test.”
Sadeghi predicts Nucleus will sequence 500,000 whole genomes by 2026
“I think we can actually, I think two years from now, we can get half a million samples. Two years from today, I think we could do that.”
Sadeghi: Standard IVF clinics ignore polygenic traits and common diseases
“These are conditions that, generally speaking, are just simply not tested in the clinic today. So let's say you're a couple doing IVF. The first thing that's very well accepted in the IVF context is making sure your child doesn't have any chromosomal abnormali…”
Sadeghi: Nucleus plans to expand into post-birth genetic testing for babies
“And so you see this testing from preconception to conception, and now even after birth, we're going to be exploring as well.”
Sadeghi: Whole-genome testing will unify ancestry, clinical screening, and IVF platforms
“Because fundamentally, through the rise of the whole genome test, you can actually combine every single one of these applications. You can combine, you know, kind of ancestry, Natera, Myriad, IVF genetic testing companies, PGX companies, all into one roof, int…”
Sadeghi shares his 99.3 percentile schizophrenia genetic risk and 1.43% overall risk
“And you can see here how, even though I'm dramatically higher genetic risk, right? 2.48, I think is in the 99.3 percentile. My overall risk is 1.43%.”
Sadeghi: One in 50 babies born today are conceived via IVF
“I mean, I think the statistic is that one in 50 babies today are born via IVF.”