Dave Burke

Advisor, Arc Institute · 1 appearance on the record.

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executiveengineerfounder@davey_burke ↗LinkedIn ↗arcinstitute.org ↗

Dave Burke spent 14 years at Google, serving as Vice President of Engineering for Android and overseeing OS and Google Pixel software as Android scaled to over 3.5 billion devices. In 2024, he joined the biomedical nonprofit Arc Institute as its inaugural CTO to lead computational technology before transitioning to an advisory role.

5statements → 2claims → 1claims resolved → 3.8/5average certainty → 1.8/5average debate potential →

1 supported 0 partly supported 0 contradicted 1 not checkable as stated how the 2 claims stand · each chip opens the sources

2 assertions · 1 opinion · 1 insight · 1 disclosure · every statement was checked. The predictions and assertions are the 2 claims: statements the public record can support or contradict. 1 is resolved, and 1 names no date, number or outcome precise enough to check. Everything else (opinions, insights, what ifs, disclosures) can never be settled by the record, so it carries no assessment.

The record, in short

What the tape says about how Dave argues and how the claims held up. Everything they said, and everything said about them, is in the tabs below.

Their most notable supported claim

Assertion Supported

Burke: Evo 2 trained on 9.3 trillion nucleotides predicts BRCA1 pathogenicity

“Like, if you look at the EVO II model, we trained it on 9.3 trillion nucleotides, but we didn't tell it anything about DNA. We just like, here's a lot of DNA on the planet across, you know, every single piece of DNA we could get a hold of. And then what di…”

Dave Burke Feb 25, 2025 ▶ 54:27 No Priors Ep. 103 | With Vevo Therapeutics and the Arc Institute

How they sound: not measured why? →

We measure speaking style by listening to the audio itself, and a fair number needs at least 2,000 words from one person on tape we have measured. There is too little of Dave Burke on measured tape to publish a rate. This says nothing about how they speak.

What they said5 Episodes1

Everything Dave Burke said on No Priors that made the record, most notable first. Filter by type, assessment or year in the ledger →

Assertion Not checkable as stated

Burke: Current virtual cell models have only around 10% predictive accuracy

“The reality is today the best models are very poor at this. like the predictive ability of the DEGs as we call them is, is in the order of 10%.”

Dave Burke Feb 25, 2025 ▶ 33:19 No Priors Ep. 103 | With Vevo Therapeutics and the Arc Institute

Opinion

Burke: Virtual cell accuracy is limited by data quality, not architecture

“One of our conjectures is that one of the reasons the models aren't doing well is not just simply model structure. We have a lot of rich structures that we understand in the ML space and machine learning space that the issue is the Data quality.”

Dave Burke Feb 25, 2025 ▶ 33:38 No Priors Ep. 103 | With Vevo Therapeutics and the Arc Institute

Disclosure

Burke: Arc Institute built SC Basecamp with 230M single cells

“We've created something called SC Basecamp and you can almost think of it like the Google crawler and index, so we've built this agent that goes onto the internet, And basically mines public single cell sequenced RNA data, and then curates it in a very sort of…”

Dave Burke Feb 25, 2025 ▶ 27:51 No Priors Ep. 103 | With Vevo Therapeutics and the Arc Institute

Insight

Burke: Transcriptomic level is the right abstraction for cell modeling

“And so I think our belief around the room is the right level of abstraction is at the sort of transcriptomic level because you have these very complex gene pathways. And so whenever a cell is changing to its environment reacting, that it will be reflected and …”

Dave Burke Feb 25, 2025 ▶ 41:59 No Priors Ep. 103 | With Vevo Therapeutics and the Arc Institute