The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 10 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 2 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Wang: X-Cell Is First to Predict Unseen Cell Line Perturbations
“One of the rewarding signals I receive after we develop Excel is that like it's a wow moment from biologists that this is the first time biologists actually find the model can predict exactly how these unseen cell lines kind of respond to different perturbatio…”
Wang: Virtual cell AI models will eventually replace physical cellular experiments
“Eventually we kind of, we can replace all the cellular experiments by simply running simulations on computer without even running the actual Experiments.”
Wang: Diffusion Outperforms Autoregressive Models on Unseen Cellular Tasks
“We find that switching from autoregressive training to division language models give a significant improvement over some of the harder tasks, particularly generalized to unseen tasks.”
Wang: Foundation models on causal data will beat linear baselines
“I believe that foundation model or other more complicated AI models that trend on the right data will outperform these linear models in harder tasks, particularly in generalization tasks.”
Wang: X-Cell Can Predict Combinatorial Gene Perturbations In Silico
“This is also why we incorporate PPI networks as the prior knowledge into our model. And although the model right now are trained on single gene perturbations, but once the model is trained, you can actually predict combinatorial perturbations just on the model…”
Wang: Next version of X-Cell will infer spatial cellular representations
“However, definitely our ongoing work and the next version of Excel will be able to infer the spatially aware representations for different cells.”
Wang: Virtual cell models will integrate multi-omics to predict cell states
“So eventually what I predict is that a virtual cell model will be able to integrate not only RNC, can integrate more functionally Related, for example, proteinomics or other regulatory side of omics such as ataxic to overall combine all your descriptive omics …”
Wang: Average single-cell profiles can beat technical replicates on MAE
“Because single cell data set are so sparse, the average profiles of all the cells, certainly you kind of, you can imagine is a great minimum kind of local optimum to minimize the MAEs. This is why sometimes the average profile of cells has lower MAEs even than…”