The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 5 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 0 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Feinberg: Studies show AlphaFold structures provided no value for drug docking
“There is this, ah, a few papers that came out, one was in Cell, I think last year, which showed that for all of the claims about AlphaFold-solving drug discovery, people try to take AlphaFold-produced protein structures, use them for traditional docking, and f…”
Kulik: Materials AI Models Can Fail Far More Catastrophically Than AlphaFold
“So it's just hard to know from experiment or from other computations if these types of models are correct, and they're certainly not correct across all of chemical space and I'd say they could fail more catastrophically than AlphaFold obviously fails, though t…”
Kulik: No Current ML Potential Robustly Models All Materials Bonding
“The challenge is that you have a lot more than 20 building blocks when it comes to materials and so there's lots of different ways to think about chemical bonding, and right now no potentials are really robustly encoding all of that bonding, especially with re…”
Zuckerberg: Synchronizing biological tool design with AI model building outperforms using legacy datasets
“Part of what we're trying to unlock here with Biohub is the idea of what actually, what happens If you do frontier biology and frontier AI in sync together and you're designing the tools on the frontier biology side in order to specifically collect and be able…”
AlphaFold Resolves Protein Structures Using Dijkstra-Like Pairwise Distance Decoding
“From this evolutionary information about potential contacts, Then it's almost as if the model is sort of running some kind of, you know, Diestro algorithm, where it's sort of decoding, okay, these have to be closed, okay, then if these are closed and this is c…”