Jeremy Wohlwend, co-founder of Boltz, discusses the state of biomolecular structure prediction across modalities beyond single-chain proteins.
Insight
AI Excels at Structure Prediction but Fails to Model Physical Folding
“Folding is the more complex process of actually understanding, like, how it goes from, like, this disordered state into, like, a structured, like, state, and that I don't think we've made that much progress on, but the idea of, like, yeah, going straight to th…”
Insight
Structure Prediction Models Degrade Without Co-Evolutionary Sequence Data
“What it implies also is that, you know, in absence of that co-evolutionary landscape, the models don't quite perform as well.”
Opinion
ML Folding Models Only Possess Localized Understanding of Physics
“I think one of the thing, at least I believe is that once you're in that sort of approximate, you know, area of the solution space, then the models have like some understanding, you know, of how to get you to like, you know, the low energy low energy state. An…”
Assertion Not checkable as stated
Compute Constraints Forced Boltz-1 to Train Once With In-Flight Bug Fixes
“And actually we only trained the big model once. That's how much compute we had. We could only train it once. And so like, while the model was training, we were like finding bugs left and right. A lot of them that I wrote. Yeah. And like, I would, I remember l…”
Insight
Current Models Fail to Predict Protein Conformational Dynamics and States
“Proteins are not static. They move, they take different shapes based on their energy states. And I think we are also not that good at understanding the different states that the protein can be in and at what frequency, what probability.”
Insight
Pairwise Representation Mechanisms Have Survived Since AlphaFold 2
“And yeah, I think too, it's really survived the test of time. I mean, you know, this thing came out in 20, 21 and it's largely the same. I mean, there's been this change to the structure module that's been like largely simplified, but where a lot of the magic …”