The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 7 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 0 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Ganguli: FDA-approved drugs target only 800 of roughly 20,000 human genes
“FDA approved drugs they target only 800 of the 20,000 known genes that we have, 20 to 25,000 known genes that we have.”
Ganguli: ESM-3 model trained on 2.8 billion amino acid sequences
“ESM-III with evolutionary scale modeling did the same language modeling, but now on amino acid sequences of about 2.8 billion sequences, right?”
Ganguli: Bringing a drug to market costs $2.5B and takes 10–15 years
“The cost of drug design, I mean, I know in the industry this is well known, but it's worth, worth emphasizing, it's 2.5 billion dollars per drug in 10 to 15 years, right?”
Ganguli: 90% of drug candidates fail to achieve FDA approval
“90% of drug candidates don't get FDA approval.”
Ganguli: Drug output per billion dollars of R&D halves every nine years
“There's this law that the number of drugs brought to market per billion dollar spend is going down by half every nine years, right?”