Assertion Supported AI assessment confidence: 95% certainty 4/5 debate potential 2/5

Meier: Chai-2 achieved a 50% success rate on tested targets

Joshua Meier · No Priors Ep. 121 | With Chai Discovery Co-Founders Jack Dent and Joshua Meier · Jul 3, 2025 · at 18:50

Joshua Meier, co-founder of Chai Discovery, discusses benchmark performance metrics for their generative antibody design model, Chai-2.

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“The model is not perfect. You know, it worked in 50% of the targets that we tried. Maybe it would have been more, right, for the caveats we talked about before, but, you know, it worked in 50% of cases.”

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More from Joshua Meier

Assertion Supported
Meier: Chai-2 maintains success rate on targets with 25% sequence similarity
“We actually even have a slide in our paper in the supplement where we actually look at an even harder subset. So not looking at things that are, you know, up to a sequence similarity with the model, but actually pushing all the way down to 25%. So really looki…”
Joshua Meier Jul 3, 2025 ▶ 17:23 No Priors Ep. 121 | With Chai Discovery Co-Founders Jack Dent and Joshua Meier
Prediction Not checkable as stated
Meier: Clinical interest in traditional monoclonal antibodies will decline
“So what we predict will happen is people probably won't be as interested in, in the clinic for things like monoclonal antibodies. These are, you know, antibodies that are hitting, for example, like a specific epitope on a protein.”
Joshua Meier Jul 3, 2025 ▶ 27:43 No Priors Ep. 121 | With Chai Discovery Co-Founders Jack Dent and Joshua Meier
Opinion
Meier: Previous AI bio startups had overly tight lab integration
“Almost every AI bio company before us has had some kind of very tight lab integration with what they are doing. And it almost too tight.”
Joshua Meier Jul 3, 2025 ▶ 3:05 No Priors Ep. 121 | With Chai Discovery Co-Founders Jack Dent and Joshua Meier
Assertion Not checkable as stated
Meier: Most AI drug discovery papers test only one to three targets
“Most of the existing papers in this area of doing AI for drug discovery are usually looking at like one, two or three targets.”
Joshua Meier Jul 3, 2025 ▶ 10:40 No Priors Ep. 121 | With Chai Discovery Co-Founders Jack Dent and Joshua Meier
Disclosure
Chai filtered benchmark targets to under 70% identity from training data
“So we actually wrote a scraper that would go and see what was in stock. We would go and pick out the protein. We would go look at what that protein sequence was. Now we need to make sure this is held out from training as well. Right? So we would take that, tha…”
Joshua Meier Jul 3, 2025 ▶ 11:39 No Priors Ep. 121 | With Chai Discovery Co-Founders Jack Dent and Joshua Meier
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