Dent: Structure prediction is biotech's ImageNet moment, molecular design is Midjourney
Jack Dent · No Priors Ep. 121 | With Chai Discovery Co-Founders Jack Dent and Joshua Meier · Jul 3, 2025 · at 14:17
Jack Dent, co-founder of Chai Discovery, explains the architectural and conceptual distinction between protein structure prediction models (like AlphaFold/Chai-1) and de novo generative molecular design (Chai-2).
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“One piece of intuition around that is that you can almost think about structure prediction as The ImageNet moment for the field, where with structure prediction, we are asking a model to go from sequence to a predicted structure, and it's sort of like a classification task. And then design, where you're trying to design binders, that is much more like a generative task. That's sort of like mid-journey for molecules”
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