Strogatz: Mathematical modeling proved three-drug therapy suppresses long-term HIV mutations
Steven Strogatz · #73 Steven Strogatz: Exploring Curiosities · Jan 7, 2020 · at 48:12
Steven Strogatz, an applied mathematician, explains how calculus and probability modeling proved the clinical necessity of triple-combination antiretroviral therapy for HIV.
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“What Perilson's math showed is that if you did two drugs, your odds were a little better, because then the virus would have to do two simultaneous mutations. The odds of that were lower than one. But three drugs would be the sweet spot where The odds were so low that HIV could mutate three simultaneous ways that you could not, you could basically keep it at bay for a long time, and that's now the modern regimen, the three-drug therapy.”
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