Kian Sadeghi

Founder & CEO, Nucleus Genomics · 1 appearance on the record.

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founderexecutive@KianSadeghi5 ↗LinkedIn ↗mynucleus.com ↗

After leaving the University of Pennsylvania in 2021, Sadeghi founded Nucleus Genomics and raised over $30 million to offer whole-genome health and embryo screening. He is known for promoting consumer access to genetic optimization, screening IVF embryos and adult genomes for polygenic disease risks and traits.

9statements → 2claims → 1claims resolved → 4.11/5average certainty → 1.78/5average debate potential →

1 supported 0 partly supported 0 contradicted 1 not checkable as stated how the 2 claims stand · each chip opens the sources

1 prediction · 1 assertion · 1 opinion · 3 insights · 3 disclosures · every statement was checked. The prediction and assertion are the 2 claims: statements the public record can support or contradict. 1 is resolved, and 1 names no date, number or outcome precise enough to check. Everything else (opinions, insights, what ifs, disclosures) can never be settled by the record, so it carries no assessment.

The record, in short

What the tape says about how Kian argues and how the claims held up. Everything they said, and everything said about them, is in the tabs below.

Their most notable supported claim

Assertion Supported

Sadeghi: 23andMe Used Microarrays Because Genome Sequencing Cost $20M in 2006

“23 and me, they got started in 2006, the cost of sequencing the genome at that point was around twenty million dollars per sample, ok. So they couldn't actually employ the technology to read the entirety of someone's DNA, all six billion letters. They opted fo…”

Kian Sadeghi May 28, 2024 ▶ 20:34 How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)

How they sound: not measured why? →

We measure speaking style by listening to the audio itself, and a fair number needs at least 2,000 words from one person on tape we have measured. There is too little of Kian Sadeghi on measured tape to publish a rate. This says nothing about how they speak.

What they said9 Episodes1

Everything Kian Sadeghi said on Founder's Journal that made the record, most notable first. Filter by type, assessment or year in the ledger →

Opinion

Sadeghi: 23andMe Offers Superficial Traits Despite Massive Advances in Genetics

“There's all this research, there's all these insights, there's all this innovation, right? But we're stuck with Do you like chocolate or not from 23 and me? Like, what's going on here, right?”

Kian Sadeghi May 28, 2024 ▶ 10:47 How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)

Disclosure

Sadeghi Cold-Emailed the Future Nucleus CSO 50 Questions Under a Pseudonym

“I emailed, under pseudonym, just to be honest with you, under pseudonym, our, again, current chief scientific officer, and I asked him, like, you know, 50 questions, right? And he was kind enough to actually, he answered all the questions.”

Kian Sadeghi May 28, 2024 ▶ 22:06 How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)

Prediction Not checkable as stated

Sadeghi: Plummeting Sequencing Costs Make a DNA Application Layer Inevitable

“There is an inevitability that there's going to be this kind of exponential proliferation in this whole genome data, and someone's going to have to build this kind of application layer for DNA, like that, that, of course that's going to happen, right? I mean, …”

Kian Sadeghi May 28, 2024 ▶ 8:16 How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)

Insight

Sadeghi: Deep Scientific Mastery Reveals the Gap Between What Could and Does Exist

“And what people don't, I think, understand or have a good intuition for is that when you get deep enough into any scientific discipline or any field, you start seeing old intellectual cracks. So you understand two things. One of the things you understand is, w…”

Kian Sadeghi May 28, 2024 ▶ 10:27 How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)

Insight

Sadeghi: Entrepreneurial Relentlessness Is Driven by Love and Fear

“If you think about relentlessness, to me it's kind of, it means like a pathological motivation. Like you're pathologically motivated. And where does pathological motivation come from? It comes from, I think, two things. It comes from love and fear.”

Kian Sadeghi May 28, 2024 ▶ 11:38 How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)

Insight

Sadeghi: Strong Intellectual Fundamentals Allow Founders to Re-Derive Anything

“If the fundamental, if the intellectual fundamentals are strong enough, you can re-derive anything.”

Kian Sadeghi May 28, 2024 ▶ 16:52 How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)

Disclosure

Sadeghi Acquired the Academic Polygenic Scoring Site of His Future CSO

“He ran this, like, academic site that gave people kind of D to C polygenic scores. It's kind of an eugenic analysis. And of course, I don't know, maybe a year later, year and a half later, we actually acquired it and bring him on.”

Kian Sadeghi May 28, 2024 ▶ 17:49 How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)

Assertion Supported

Sadeghi: 23andMe Used Microarrays Because Genome Sequencing Cost $20M in 2006

Kian Sadeghi May 28, 2024 ▶ 20:34 How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)

Disclosure

Sadeghi: Call Early Work Research Rather Than a Company to Reduce Pressure

“I actually had a rule to myself. The rule was I would not say anything about a company. It's a project. It's, I, I'm just doing research.”

Kian Sadeghi May 28, 2024 ▶ 35:16 How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)

Appearances (1)

Episode	Date	Speaking time
How to Become Relentless as an Entrepreneur (Kian Sadeghi, Nucleus)	May 28, 2024	22m

Kian Sadeghi

The record, in short

Their most notable supported claim

How they sound: not measured why? →

Appearances (1)

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