The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 9 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 0 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Sadeghi: 23andMe Offers Superficial Traits Despite Massive Advances in Genetics
“There's all this research, there's all these insights, there's all this innovation, right? But we're stuck with Do you like chocolate or not from 23 and me? Like, what's going on here, right?”
Sadeghi Cold-Emailed the Future Nucleus CSO 50 Questions Under a Pseudonym
“I emailed, under pseudonym, just to be honest with you, under pseudonym, our, again, current chief scientific officer, and I asked him, like, you know, 50 questions, right? And he was kind enough to actually, he answered all the questions.”
Sadeghi: Plummeting Sequencing Costs Make a DNA Application Layer Inevitable
“There is an inevitability that there's going to be this kind of exponential proliferation in this whole genome data, and someone's going to have to build this kind of application layer for DNA, like that, that, of course that's going to happen, right? I mean, …”
Sadeghi: Deep Scientific Mastery Reveals the Gap Between What Could and Does Exist
“And what people don't, I think, understand or have a good intuition for is that when you get deep enough into any scientific discipline or any field, you start seeing old intellectual cracks. So you understand two things. One of the things you understand is, w…”
Sadeghi: Entrepreneurial Relentlessness Is Driven by Love and Fear
“If you think about relentlessness, to me it's kind of, it means like a pathological motivation. Like you're pathologically motivated. And where does pathological motivation come from? It comes from, I think, two things. It comes from love and fear.”
Sadeghi: Strong Intellectual Fundamentals Allow Founders to Re-Derive Anything
“If the fundamental, if the intellectual fundamentals are strong enough, you can re-derive anything.”
Sadeghi Acquired the Academic Polygenic Scoring Site of His Future CSO
“He ran this, like, academic site that gave people kind of D to C polygenic scores. It's kind of an eugenic analysis. And of course, I don't know, maybe a year later, year and a half later, we actually acquired it and bring him on.”
Sadeghi: 23andMe Used Microarrays Because Genome Sequencing Cost $20M in 2006
“23 and me, they got started in 2006, the cost of sequencing the genome at that point was around twenty million dollars per sample, ok. So they couldn't actually employ the technology to read the entirety of someone's DNA, all six billion letters. They opted fo…”