Eli Lilly CEO Dave Ricks describes how pharmacy middlemen and health insurers initially shunned Lilly's low-list-price authorized generic insulin because it undermined PBM rebate margins.
“In the first year, no formularies covered this. So it was really only for that cash payer. No insurance company picked it up, even though it was dramatically cheaper. Now it's about half of the volume, but still half not because that model of this margin spread model is still there.”
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More from Dave Ricks
Opinion
Ricks: PBM rebate incentives should be eliminated as unethical
“These PBMs and there's some group purchasing organizations like this. That should go away. And I think health is different than other commodities. It's probably has a much more important social role in deciding that the smallest, the little guy gets the worst …”
Dave RicksNov 11, 2025▶ 39:48Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
PredictionPartly held up
Ricks: Machine-designed drugs haven't reached clinical trials yet, but are coming
“I don't know of one that's come through the machine driven discovery process, which is really machine plus human that's made it to the clinic yet, but they're coming.”
Dave RicksNov 11, 2025▶ 3:19Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
Insight
Ricks: AI won't solve biology until we understand over 50% of it
“And today, I don't know, I would estimate we might know 10 to 15% of human biology. So the machine's not going to be good at all until we get way above 50%.”
Dave RicksNov 11, 2025▶ 4:35Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
Opinion
Ricks: Claude and xAI beat ChatGPT for science because references check out
“I don't use that one for science actually. It's too, too horrible.
Patrick Collison: So which one do you use for science?
Dave Ricks: I tend to use either Claude or the XAI one. I find it more terse. And more, the references actually check out more often.”
Dave RicksNov 11, 2025▶ 5:59Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
Opinion
Ricks: Lilly's industry-leading R&D ROI comes from process, not picking winners
“I think one of the reasons Lilly has probably the highest return on investment in R&D in the industry is because not the picking of winners and losers, but the, actually the process by which we run it.”
Dave RicksNov 11, 2025▶ 10:54Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
AssertionPartly supported
Ricks: Cardiovascular trial rules added five years to diabetes drug development
“The Evandia one, we know well, we work in diabetes, actually caused a policy change, and the policy change was you must rule out cardiovascular risk prior to market entry, and as you may know some conditions like diabetes have a more continuous variable you're…”
Dave RicksNov 11, 2025▶ 23:28Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
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