The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
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Orca Bio clinical data shows practically zero transplant-related patient mortalities
“Well, we'll see, but the data so far suggests that we can bring it down to practically zero, right? Zero transplant related mortalities.”
Novartis shut down Irv Weissman's promising breast cancer cell therapy program
“They had really incredible results in terminal breast cancer patients, and it was ultimately acquired by Sandoz slash Novartis, and everyone thought that was going to be delivered to patients, but You know, they shut down the whole program two years later, and…”
Immune resets for leukemia patients have serendipitously eliminated MS and HIV
“There are sort of serendipitous situations where people have had, for example, really severe autoimmune diseases like multiple sclerosis, happen to also have leukemia on the side. For the leukemia, they get an immune system reset, and then they, you know, magi…”
Safe immune resets could eventually treat tens of millions of patients
“And I think the, you know, ultimately, if this keeps progressing the way that we've seen it so far, there's no reason why you couldn't be helping tens of millions of patients.”
Orca Bio must compress multi-year drug distribution cycles into 72 hours
“If you look at a regular medicine from the moment you get the raw material until you ship it to the factory, you build the pills and then you ship, you have the whole distribution network and all the warehousing until it gets to the hospital and ultimately get…”
Single-dose curative cell therapies disrupt healthcare payment models requiring upfront billing
“Because you have to condense all of the regular payments that you do when you take a pill. You might take a pill for many years. You have to condense them all into one payment because at the end of the day, this is a single dose curative medicine.”
Laser cell-sorting technology accelerates processing speeds by orders of magnitude
“So we have a whole stack of technologies that the technology you mentioned is sort of the accelerator to be able to broaden it out to really huge numbers of patients, where we're basically using lasers and light to move cells around and sort them, and, That ca…”
FDA clears Orca Bio for clinical trials treating multiple sclerosis
“We recently actually just got clearance from the FDA to begin clinical trials with multiple sclerosis patients with our second gen product, OrcaQ.”
No existing medication stops the progression of primary progressive multiple sclerosis
“There's really no medication that stops the progress there.”
Regenerative cell therapies will solve intractable degenerative diseases and expand human lifespan
“I mean, there's definitely stem cells for hair, and I know a few companies working on it, so we could probably regenerate that too, and I think you're going to see a lot of these totally intractable problems now start to be within the realm of being solvable, …”
Cell therapies uniquely self-manufacture and expand within the patient's body
“And if you think of the cell as the actual active ingredient of the medicine, the actual medicine is a cell. What you're seeing there is that the, that, that the medicine is self manufacturing within your body and expanding, right? You could never do that with…”