The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 9 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 0 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Chan: Scientists thought CZI's goal to cure all disease was crazy
“When we first set out that, the goal to cure and prevent disease by the end of the century, people, like, honestly, Most scientists couldn't look at us with a straight face. And they're like, you're crazy. Yes. And it was true because if you just decided to sp…”
Chan: Most medical conditions should be treated as rare diseases
“And so those are rare, like, and, but I really think most diseases should be thought of as rare diseases. Because each one of our biology is different.”
Chan: CZI built a 1,000-GPU cluster and plans a 10,000-GPU expansion
“We were the first to really build a large-scale compute cluster. A thousand now where we have plans to move to the 10,000 range.”
Chan: LLMs provided the breakthrough needed to analyze CZI's biological datasets
“We were already Building tools to measure interesting data. Building the data sets. But we didn't really know what to do with them yet. And large language models coming onto the scene, we're like, wow, we can make sense of all of this now.”
Chan: Virtual cell models provide utility even without perfect accuracy
“But I don't think it needs to be a hundred percent accurate to be useful. Because you just want to be able to de-risk the idea on the front end a little bit. And the more and more you de-risk it, the more efficient it gets, obviously. But it'll be useful if yo…”
Chan: CZI is consolidating biohubs and AI teams into one philanthropy
“Under Alex's leadership, we are going to come together as the biohub, a an operating philanthropy where we are doing the science,”
Chan: How CZI selects 10-to-15-year scientific Grand Challenges
“When we looked at the Grand Challenges for, on the 10 to fifteen-year time horizon, it needs to be, like, when you look at it, you're like, I see a path. Not everything needs to be solved for us to take it on. In fact, if everything's solved, then that feels l…”
Chan details the specific research focuses of CZI's three Biohubs
“We have three biohubs. We have one in San Francisco, one in Chicago, one in New York. The one in New York works on cell engineering. You know, can we engineer cells To go in and detect signals, read it out, or to take certain actions. In Chicago, we're buildin…”