Priscilla Chan, co-founder of CZI, responds to questions about model accuracy by explaining how imperfect simulation models still de-risk biological research.
“But I don't think it needs to be a hundred percent accurate to be useful. Because you just want to be able to de-risk the idea on the front end a little bit. And the more and more you de-risk it, the more efficient it gets, obviously. But it'll be useful if you even get directional signal.”
quote is from the automated transcript, cleaned for reading:
filler sounds and stutters are removed, nothing is rephrased. names can be misheard
(the analysis reads context, assessments check outside sources). how →
More from Priscilla Chan
AssertionNot checkable as stated
Chan: Scientists thought CZI's goal to cure all disease was crazy
“When we first set out that, the goal to cure and prevent disease by the end of the century, people, like, honestly, Most scientists couldn't look at us with a straight face. And they're like, you're crazy. Yes. And it was true because if you just decided to sp…”
Priscilla ChanNov 6, 2025▶ 0:24Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease
Opinion
Chan: Most medical conditions should be treated as rare diseases
“And so those are rare, like, and, but I really think most diseases should be thought of as rare diseases. Because each one of our biology is different.”
Priscilla ChanNov 6, 2025▶ 13:31Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease
AssertionSupported
Chan: CZI built a 1,000-GPU cluster and plans a 10,000-GPU expansion
“We were the first to really build a large-scale compute cluster. A thousand now where we have plans to move to the 10,000 range.”
Priscilla ChanNov 6, 2025▶ 39:32Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease
Disclosure
Chan: LLMs provided the breakthrough needed to analyze CZI's biological datasets
“We were already Building tools to measure interesting data. Building the data sets. But we didn't really know what to do with them yet. And large language models coming onto the scene, we're like, wow, we can make sense of all of this now.”
Priscilla ChanNov 6, 2025▶ 11:08Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease
PredictionHeld up
Chan: CZI is consolidating biohubs and AI teams into one philanthropy
“Under Alex's leadership, we are going to come together as the biohub, a an operating philanthropy where we are doing the science,”
Priscilla ChanNov 6, 2025▶ 28:34Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease
Disclosure
Chan: How CZI selects 10-to-15-year scientific Grand Challenges
“When we looked at the Grand Challenges for, on the 10 to fifteen-year time horizon, it needs to be, like, when you look at it, you're like, I see a path. Not everything needs to be solved for us to take it on. In fact, if everything's solved, then that feels l…”
Priscilla ChanNov 6, 2025▶ 9:27Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease
Made with StarZero
Turn any episode into a week of clips.
This entire site, over 1,000 episodes transcribed, diarized, checked and made playable,
runs on the StarZero media pipeline. Drop in your own episode and the podcast clipper finds the
moments worth sharing, cuts them, captions them, and reframes them for every feed.
We use essential cookies to make the site work. With your permission we
also use analytics cookies (Google Analytics and Mixpanel) to understand
usage and improve StarZero. See our Cookie Policy.