The Ledger
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Sinclair: Metformin and NAD boosters reduced calculated biological age from 57 to 31
“I took metformin, Kristen mentioned, which is a diabetes drug. I took another molecule that we've worked on called, it raises NAD, we call them NAD boosters, and I saw that my bio-age, according to this algorithm, went down to 31.4 from 57 point something, and…”
Sinclair: Longevity tools will extend human lifespan by 5 to 15 years
“And those three combined, I think, are going to dramatically increase human health span and lifespan by somewhere between five and 15 years in our lifetimes.”
Sinclair: Epigenetic reprogramming could enable five-year biological age resets
“There is actually evidence in a mouse that you can reverse some of those so-called epigenetic analog changes with aging, and that's truly the next frontier in my view, because that really could lead to true Aging reset, and you just go to the doctor every five…”
Sinclair: Companies he advises are running anti-aging human trials
“A couple of companies that I work with have been doing trials for a number of years now, and they seem to be working as advertised, but it's pretty hard to actually show that they're reversing aging. So we're going off to particular diseases.”