Assertion Supported AI assessment confidence: 92% certainty 5/5 debate potential 1/5

Lopez: 85% of dogs with bladder cancer carry V600E BRAF mutation

Christina Lopez · a16z Podcast | Connecting Hearts, Bodies, and Networks to Cure Cancer · Feb 26, 2019 · at 18:48

Christina Lopez discusses canine genetic markers and precision medicine research into cancer drivers in dogs.

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“85% of dogs with transitional cell carcinoma are BRAF positive, and it's V 600 E BRAF, very particular.”

quote is from the automated transcript, cleaned for reading: filler sounds and stutters are removed, nothing is rephrased. names can be misheard (the analysis reads context, assessments check outside sources). how →

The claim, plainly

85% of dogs diagnosed with transitional cell carcinoma are positive for the V600E BRAF mutation.

a quote alone can be ambiguous, so this restates it with the references and context of the conversation around it resolved. AI-written; the tape below the player is the source.

Assessment

Veterinary oncology literature and standard commercial diagnostic assays (such as the CADET BRAF ddPCR assay) establish that approximately 85% (studies typically reporting 80% to 87%) of canine transitional cell carcinoma (TCC) cases harbor an activating BRAF mutation. In dogs, the mutation is specifically BRAF V595E, which is the direct orthologue of the human BRAF V600E mutation and is widely referenced as such in comparative oncology.

Decker et al. (2015, Molecular Cancer Research) identified that 87% of 62 canine invasive TCC tumors carried the somatic BRAF V595E mutation (homologous to human V600E).
Mochizuki et al. (2015, PLOS ONE) reported BRAF mutation prevalence of approximately 80% in canine urothelial/transitional cell carcinoma.
Commercial diagnostic platforms such as Sentinel Biomedical / Antech's CADET BRAF test widely benchmark an 85% detection rate for canine TCC/UC cases.

Checked against

[1] nih.gov [2] aacrjournals.org [3] laboklin.com [4] mdpi.com [5] akc.org [6] soundvet.com [7] axiomvetlab.com [8] nih.gov

Sentinel Biomedical Cadet BRAF canine TCC 85 percent canine urothelial carcinoma BRAF V600E mutation frequency 85 BRAF V600E mutation canine transitional cell carcinoma 85 percent canine transitional cell carcinoma BRAF mutation percentage prevalence

assessed as of 2026-08-27

This assessment is an AI reading of a public statement, made against the cited references with the confidence shown. It can be wrong. The quote, the tape and the references are all on this page; if something is off, use report an error below. full disclaimer →

Mentioned

BRAF transitional cell carcinoma

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