Christina Lopez contrasts naturally occurring canine cancers with lab-engineered mouse models, highlighting the critical role of functional immune systems in immuno-oncology research.
“Dogs that have natural disease, spontaneous disease, have an immune system also that's working, and that's a radical difference from the mice models that are much more engineered and sometimes don't have an immune system to have the cancer, and then the ones that they really try to figure out to, you know, have immune system and cancer last 20 days.”
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More from Christina Lopez
AssertionPartly supported
Lopez: Dog Breeds Living Near Golf Courses Suffer Higher Bladder Cancer Rates
“Certain breeds near golf courses have had actually bladder cancer, transitional cell carcinoma, it's actually an area of study.”
Christina LopezFeb 26, 2019▶ 2:15a16z Podcast | Connecting Hearts, Bodies, and Networks to Cure Cancer
AssertionSupported
Lopez: One Health built the first NGS panel for dogs
“We have the first next gen sequencing panel for dogs.”
Christina LopezFeb 26, 2019▶ 21:08a16z Podcast | Connecting Hearts, Bodies, and Networks to Cure Cancer
AssertionSupported
Lopez: Canine Genomics Lacks NIH Research Funding Compared to Mouse Models
“Veterinary medicine has not had the resources, and even from the NIH level, what the mouse has been very well characterized and studied, the dog really hasn't.”
Christina LopezFeb 26, 2019▶ 2:47a16z Podcast | Connecting Hearts, Bodies, and Networks to Cure Cancer
AssertionSupported
Lopez: Canine trials saved the development of lymphoma drug ibrutinib
“And you know the story of rebrutinib, a lymphoma drug that, you know, the dog and the human, and actually the evidence from the dog helped not just this company be alive, but the drug be alive”
Christina LopezFeb 26, 2019▶ 11:29a16z Podcast | Connecting Hearts, Bodies, and Networks to Cure Cancer
AssertionSupported
Christina Lopez: Canine cancer probability increases significantly after age five
“And if you correlate cancer with aging, the dogs after the age of even five, the probability of cancer goes way up.”
Christina LopezFeb 26, 2019▶ 15:25a16z Podcast | Connecting Hearts, Bodies, and Networks to Cure Cancer
AssertionNot checkable as stated
Lopez: Veterinary oncology relies on only 13 total cancer therapies
“The toolbox is probably 13 therapies in total that we were talking about with Cheryl London, one of our KOLs that's really top in canine oncology, total.”
Christina LopezFeb 26, 2019▶ 17:03a16z Podcast | Connecting Hearts, Bodies, and Networks to Cure Cancer
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