Jim Collins

9 statements across 1 episodes · 3 bullish · 1 bearish · 1 people on the record · first statement Jan 17, 2019 by Jim Collins · said 1 times in 1 episodes since 2019 · across every show →

On the record as a speaker too: Jim Collins's record, appearances and statements → this page counts the times other people say the name.

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Everything said about Jim Collins, oldest first

Jan 17, 2019 positive
Insight
Jim Collins: Engineering models have predictive value without mechanism knowledge
“An engineer can do remarkably well in many instances with little, if any, understanding of mechanism. And that we'll get after a black box. You can represent a model that gives you some sense of relation between the input and output of, say, going back to our …”
Jim Collins Jan 17, 2019 ▶ 11:57 a16z Podcast | All About Synthetic Biology
Jan 17, 2019
Assertion Supported
Jim Collins: Synthetic biology team built functional genetic toggle switch in nine months
“Nonetheless, in nine months, he had a functioning bistable toggle switch.”
Jim Collins Jan 17, 2019 ▶ 8:24 a16z Podcast | All About Synthetic Biology
Jan 17, 2019
Assertion Not checkable as stated
Collins: Leading molecular biologists insisted synthetic genetic toggle switches were impossible
“We had talked to about six or seven very serious molecular biologists who told us this couldn't happen, this couldn't work. They said for it to work, you're going to have to have a very tight off state, two very tight off states. That's going to be impossible.…”
Jim Collins Jan 17, 2019 ▶ 7:30 a16z Podcast | All About Synthetic Biology
Jan 17, 2019
Assertion Not checkable as stated
Jim Collins: Engineers in his lab resist using directed evolution
“I've been in the SynBio world now for about two decades, and I have yet to get significant buy-in from the engineers in my lab for doing directed evolution.”
Jim Collins Jan 17, 2019 ▶ 19:18 a16z Podcast | All About Synthetic Biology
Jan 17, 2019 positive
Assertion Not checkable as stated
Collins: Companies are using synthetic circuits to program pathogen-resistant plants
“You're increasingly seeing companies turn towards synthetic circuits to Alter traits in a programmable fashion of plants and to enable them to be more robust to pathogens.”
Jim Collins Jan 17, 2019 ▶ 34:27 a16z Podcast | All About Synthetic Biology
Jan 17, 2019 bullish
Prediction Not checkable as stated
Collins: Synthetic bio will drive carbon capture and coral restoration within a decade
“I think climate is really just beginning to excite the community and broadly environmental issues on two counts. One is in what way could we use algae and other organisms to pull more carbon out of the atmosphere? Can we help reverse the trend on using biology…”
Jim Collins Jan 17, 2019 ▶ 34:37 a16z Podcast | All About Synthetic Biology
Jan 17, 2019 negative
Insight
Collins: Single-gene knockout attribution is absurd from a systems standpoint
“I maintain that in almost every biology experiment paper I've read, they've never had the controls that I'd like to see. Which is the idea that you can knock out a gene and that what's lacking and now can be attributed to the gene is absurd from a system stand…”
Jim Collins Jan 17, 2019 ▶ 10:19 a16z Podcast | All About Synthetic Biology
Jan 17, 2019
Assertion Partly supported
Collins: Only seven public microarray datasets existed in the late 1990s
“And when I got pulled in, there were only seven publicly available data sets. So the idea you could reverse engineer large scale network was ludicrous.”
Jim Collins Jan 17, 2019 ▶ 4:08 a16z Podcast | All About Synthetic Biology
Jan 17, 2019 neutral
Assertion Supported
Collins: 30% to 40% of E. coli genes remain functionally unannotated
“There still is a high percentage of the genes that are not functionally annotated in E. Coli, 30 to 40%.”
Jim Collins Jan 17, 2019 ▶ 13:05 a16z Podcast | All About Synthetic Biology
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