Alexander Bisignano

Biotech Founder & Investor · 1 appearance on the record.

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Alexander Bisignano is a genomics entrepreneur who co-founded Recombine, a clinical carrier screening company acquired by CooperSurgical, and later founded Phosphorus Labs. Selected for Forbes 30 Under 30 in Healthcare, he specializes in next-generation sequencing assays, bioinformatics platforms, and reproductive genetics.

9statements → 6claims → 5claims resolved → 40%fully supported → 4/5average certainty → 1.89/5average debate potential →

2 supported 1 partly supported 2 contradicted 1 not checkable as stated how the 6 claims stand · each chip opens the sources

6 assertions · 2 opinions · 1 insight · every statement was checked. The predictions and assertions are the 6 claims: statements the public record can support or contradict. 5 are resolved, and 1 names no date, number or outcome precise enough to check. Everything else (opinions, insights, what ifs, disclosures) can never be settled by the record, so it carries no assessment.

The record, in short

What the tape says about how Alexander argues and how the claims held up. Everything they said, and everything said about them, is in the tabs below.

Their most notable supported claim

Assertion Supported
Bisignano: Most genetic research is based on European and Jewish populations
“Most of genetics actually is based on studying European and Jewish individuals just because that's been the body of literature that's been developed over the past few decades.”
Alexander Bisignano Feb 18, 2015 ▶ 13:02 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)

Their most notable contradicted claim

Assertion Contradicted
Bisignano: Human genome sequencing costs fell from $3B to $1,000
“We finished the human genome, and then for the next decade, the human genome, the cost to sequence it went from three billion down to 1000.”
Alexander Bisignano Feb 18, 2015 ▶ 4:16 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)

Expressed certainty vs assessment result

none yet certainty 1
none yet certainty 2
none yet certainty 3
63% certainty 4
0% certainty 5

weighted support: a fully supported claim counts one, a partly supported claim counts half. Each filled bar is clickable and opens exactly those claims; "none yet" means nothing said at that certainty level has resolved yet

How they sound: speaking style how? →

248 words/min while actually speaking · 43.9 um and uh per 1k words

No argument clarity score for Alexander Bisignano: only 1 usable question→answer exchange on raw tape (a fair score needs 8+). We do not score a sample that small. Roundtable and news formats yield far fewer direct exchanges than interviews.

Measured by listening to the audio itself: 3,830 words across 1 episode of raw-level tape, transcribed verbatim with every um and uh kept, each one attributed only where the alignment onto our timed stream is unambiguous. These are measurements of speaking style. We do not rank them: across this corpus, fluency and argument quality are nearly uncorrelated (ρ≈0.2), and smooth talking does not signal clear thinking. How it's measured →

Everything Alexander Bisignano said on the MAD Podcast that made the record, most notable first. Filter by type, assessment or year in the ledger →

Assertion Partly supported
Bisignano: Science has not truly sequenced the entire human genome
“We actually haven't truly sequenced the whole human genome just because there's so much variation that we can't capture yet.”
Alexander Bisignano Feb 18, 2015 ▶ 13:49 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)
Opinion
Bisignano: LabCorp and Quest hold an oligopoly on insurance contracts
“LabCorp and Quest have sort of an oligopoly on insurance contracts, and people tend to stay in network.”
Alexander Bisignano Feb 18, 2015 ▶ 21:02 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)
Opinion
Bisignano: Major diagnostic companies Quest and LabCorp lack agile software teams
“Most laboratory diagnostic companies are not set up as software companies. Example, Quest and LabCorp. Two largest companies in the country that do laboratory testing. Twelve billion dollar market cap. They are not agile software teams.”
Alexander Bisignano Feb 18, 2015 ▶ 4:55 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)
Assertion Supported
Bisignano: Most genetic research is based on European and Jewish populations
“Most of genetics actually is based on studying European and Jewish individuals just because that's been the body of literature that's been developed over the past few decades.”
Alexander Bisignano Feb 18, 2015 ▶ 13:02 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)
Assertion Not checkable as stated
Bisignano: Recombine achieves over 65% patient opt-in rate for research
“We see a 65% or more opt-in from most of the centers”
Alexander Bisignano Feb 18, 2015 ▶ 19:08 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)
Assertion Contradicted
Bisignano: Human genome sequencing costs fell from $3B to $1,000
“We finished the human genome, and then for the next decade, the human genome, the cost to sequence it went from three billion down to 1000.”
Alexander Bisignano Feb 18, 2015 ▶ 4:16 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)
Assertion Contradicted
Bisignano: US has one genetic counselor per 250,000 people
“Right now there's about one genetic counselor for every 250,000 individuals in the U.S.”
Alexander Bisignano Feb 18, 2015 ▶ 8:27 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)
Assertion Supported
Recombine offers a 250-disease genetic test for under $500 out-of-pocket
“We developed a test that can do 250 of the most common diseases of this nature for under 500 dollars to patients that don't have private insurance”
Alexander Bisignano Feb 18, 2015 ▶ 15:06 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)
Insight
Bisignano: DNA and RNA represent nature's first digital storage system
“DNA and RNA are the two primary ways of storing information for biological organisms, and it's actually the first digital storage system, which is pretty interesting to think about it from that perspective.”
Alexander Bisignano Feb 18, 2015 ▶ 0:47 Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital)

Appearances (1)

EpisodeDateSpeaking time
Alexander Bisignano, Recombine // Genetic Testing // Data Driven NYC (FirstMark Capital) Feb 18, 2015 17m
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