The Ledger
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Hari warns of opioid-scale death toll from GLP-1 eating disorder misuse
“I think we get an opioid like death toll of young girls who use these drugs to starve themselves.”
Hari: Obesity explodes when populations switch to ultra-processed foods, not from laziness
“Obesity explodes everywhere that makes one change. It's not where people suddenly lack willpower or become lazy. It's where people move from mostly eating a diet based on whole fresh foods that they prepare on the day they eat them. To mostly eating a diet of …”
Hari: Over half the population will take GLP-1s once off-patent
“Eight years from now, Ozempic goes out a patent. At that point, it will be a daily pill. It will be a dollar a day. If the 12 big risks that I warn about in relation to these drugs don't bear out or are not as, are not super bad, then my prediction is that mor…”
Hari: Ozempic costs $250 monthly in Britain versus $1,000 in America
“So I buy my Zen pick here in Britain. It's the equivalent of, 250 dollars a month. When I, I've had to get it in Vegas a few times, it's like a thousand dollars a month, right?”
Hari: Diet and exercise fail sustained weight loss for 85% of people
“This is really important for understanding why the alternative to these drugs, diet and exercise does not produce sustained weight loss for about 85% of people who try it.”
Hari: FDA warns on GLP-1 suicidal ideation while EMA disagrees
“It did not persuade the European Medicines Agency, although the FDA in the United States does have a warning about potential suicidal ideation from these drugs.”
Hari: Bariatric surgery almost quadruples suicide risk
“After bariatric surgery, your suicide risk almost quadruples.”
Hari: Novo Nordisk is running GLP-1 trials in six-year-olds
“Novo Nordisk is currently doing a trial on giving them to six-year-olds.”
Hari: 47% of Americans want to take new weight loss drugs
“47% of Americans want to take these new weight loss drugs because they produce an incredible amount of weight loss that I'm sure we're going to unpack.”
Hari: 67% of US children's calories come from ultra-processed food
“67% of the calories the average American child consumes in a day come from processed and ultra processed foods.”
Hari: Counterfeit compounded semaglutide caused comas in Austria
“In Austria recently, there was a big problem where people bought what they thought was compounded semaglutides, the active component of these drugs. They weren't, they went into comas, they were horribly injured.”
Hari: Most patients regain most weight within a year of stopping GLP-1s
“And they have funded studies that, a study that seems to demonstrate the vast majority of people regain the vast majority of their weight within a year.”
Hari: Japan has statistically zero childhood obesity due to government policy
“I went to Japan where there is no childhood obesity. That's not an overstatement. There's statistically no childhood obesity.”
Hari: Low protein in processed food drives biological overeating
“There's a brilliant scientist at the University of Sydney called Professor David Raubenheimer, who's done a lot of research on this. He's shown, we all know we have hunger for calories, obviously, we all know that, but your body also has a hunger specifically …”
Hari: Mounjaro users average 21% weight loss in one year
“With Munjaro, so Ozempic and Wegovy work on one gut hormone, GLP-I. Munjaro works on two gut hormones, it's GLP-I and GIP. The average person who takes that loses 21% of their body weight in a year.”
Hari: Triple G agonists yield 24% weight loss, near bariatric surgery
“And for Triple G, which will be coming online probably next year, Which acts on three gut hormones. The average person loses 24% of their body weight, which is only slightly below bariatric surgery.”
Hari: Over 200 gut hormone appetite drugs are in development
“And there are now more than 200 of these drugs in development because we know there's over 40 gut hormones that affect appetite.”
Hari: Harvard research finds obesity causes 680,000 annual US deaths
“Professor Gerald Mand at Harvard calculates that obesity and food caused illnesses caused 680,000 deaths every year in the United States.”
Hari: GLP-1 weight loss drugs act primarily on brain, not gut
“So we now know these drugs are primarily working, not on your gut, but on your brain.”
Hari: Bariatric surgery cuts all-cause mortality by 40%
“If you have bariatric surgery in the seven years that follow, you are 56% less likely to die of a heart attack. You are 60% less likely to die of cancer. You are 92% less likely to die of diabetes related causes. In fact, it's so good for your health. In those…”
Hari: Obesity at age 18 carries a 70% lifetime diabetes risk
“If you're obese when you're 18 years old, you have a 70% chance of developing diabetes in your life, and diabetes, type two diabetes, knocks 15 years off your life on average”