The Ledger
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Scientific understanding of approved drugs remains severely limited
“Even for drugs that are on the market, and have been used for many years, our ability to really describe what they actually do is very limited.”
Combining Paxil and Pravastatin causes unexpected spikes in blood glucose levels
“And in one story that I'll just summarize very briefly, we looked for drugs that might cause glucose in, glucose increases, diabetes, if you will, in combination, where individually, they did nothing. So we had a very strong signal that the drugs, when taken a…”
Microsoft search logs revealed unreported side effects of combining common drugs
“In a collaboration with Microsoft, we looked at what people who were on, well, we don't know if they were on these drugs. We just looked at search logs and said, how often do people type in these two drugs and words that might be associated with the symptoms o…”
Data mining reveals tens to hundreds of unlisted side effects per drug
“We were able to find replicate what was on the drug label, but using the exact same methods, we were able to find tens or hundreds of extra side effects per drug with very high confidence from looking at a combination of FDA records and electronic medical reco…”
Pharma must mine social media and online portals for side effects
“All of these also, it's clear, I think, to most pharmaceuticals have to be sources of data, both for understanding the actions of these drugs, but also understanding the patient preferences about which symptoms of these diseases they're really most interested …”
Insights for repurposing drugs come from side effects, not approved labels
“If you're going to repurpose a drug, though, All the information in the drug label that was focused on getting you approved for one indication is not going to be where you're going to get the insight about the new uses. You're going to get the insight about th…”
7% of European descendants cannot convert codeine into morphine
“Seven percent of people of European descent don't have a version, because of genetic differences in that enzyme, they can't turn codeine into morphine.”
Genomic information systems will guide personalized drug prescribing
“Knowing a little bit about your genetics will allow us in the future to implement this vision of an information system with knowledge of your genome securely, which can then help your prescriber make decisions about the drugs that are most likely to work and t…”