The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 8 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 1 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Hsu: Physical synthesis and testing will remain AI drug discovery's bottleneck
“If we play this out, right? And let's say these AI models work, right? And you can make a trillion binders in silico that will, you know, be exquisite drug matter, right? We still need to make these things physically and test them in animals and hopefully pred…”
Hsu: Arc Institute's moonshot is building virtual cells using foundation models
“Our moonshot is really to make virtual cells at Arc and simulate human biology with foundation models, and, you know, we'd like to figure out something that feels useful for experimentalists, people who are skeptical about technology, you know, they just want …”
Hsu: Virtual cell models will advance from single cells to whole animals
“There are going to be different phases of capability where initially they model individual cells, then they model pairs of cells, then they model cells in a tissue, and then in a broader physiologically intact animal environment, and those are length scales an…”
Hsu: Scaling single-cell screens alone will feel dated in three years
“We weren't just going to be an engineering shop that's just trying to scale single cell perturbation screens, right? That You know, would be interesting, but in three years would feel very dated, I think, right?”
Hsu: Cell responses to chemical and environmental perturbations will be predictable
“Obviously, we want to be able to predict drug toxicity. We want to be able to predict aging. We want to be able to predict why a liver cell becomes cirrhotic when you repeatedly challenge it with ethanol molecules or whatever, right? And, you know, the, these …”
Hsu: Arc Institute will soon generate one billion perturbed single cells
“And at ARC in the next, you know, kind of end, like, I don't know, relatively short amount of time, we're going to generate a billion perturbed single cells, right?”
Hsu: AI will become a native part of drug discovery in years
“I feel like in, you know, I mean, increasingly in just a few years, this will just be a native part of the stack, right? Just like we use You know, the internet and we use phones. We're going to have AI in all parts of the stack, right? And so it's just going …”