The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 14 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 0 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Zuckerberg: AI will help cure all diseases significantly before 2100
“When we started the mission to see if we could help the scientific community cure and prevent diseases by the end of the century. I do think with the advances in AI, that should be possible to do significantly sooner.”
Zuckerberg: CZI is the first to combine frontier AI and biology
“There are labs that do frontier AI that basically, you know, are building the most advanced models. And then there are, Lots of biological research organizations that, that effectively do very leading edge research to build you know, to either discover new dat…”
Zuckerberg: Meta protein researchers led by Alex Rives join CZI
“We actually had a bunch of researchers who'd formerly worked at Meta on protein folding models is joining a biohub and Alex Reeves, the leader of it is actually going to be the kind of head of the whole science program”
Zuckerberg: CZI will combine biohub models into a general virtual cell
“So we'll, we'll, we'll build the biohubs around grand biological challenges. The biohubs will build tools that will generate novel data sets. We will build models based on those and then eventually combine the models into an increasingly general view of a virt…”
Zuckerberg: Virtual cell modeling requires a hierarchical protein-to-cell strategy
“Part of the hypothesis is that you can look at all these different cells and you can kind of simulate how they might behave, but you're gonna have a somewhat shallow understanding unless you actually have this hierarchical understanding of what how the subcomp…”
Zuckerberg: Biology still lacks a periodic table equivalent in 2025
“It still seems like there could be a lot more effort in this space around building tools, and it's kind of this crazy thing that we're, you know, here in, you know, twenty-twenty-five, and there's not the kind of periodic table of elements equivalent for biolo…”
Zuckerberg: Scientific breakthroughs are driven by new observation tools
“And the theory that we had was if you look at the history of science, most major breakthroughs are basically preceded by the invention of a new tool to observe phenomena in a new way.”
Zuckerberg: NIH grants are too small and near-term for major breakthroughs
“And I think that that there's a niche that I think fits that, because if you look at how funding works in science, you know, the vast majority of funding comes from the government and NIH grants. It's parceled out into these relatively small grants that allow …”
Zuckerberg: AI is simultaneously the most overestimated and underestimated technology ever
“AI's gotta be the most overestimated and underestimated technology ever, like simultaneously.”
Zuckerberg: Biohub is now the main focus of CZI philanthropy
“Actually when we started CZI, we kind of actually focused on a number of areas. And what we found is just that The science research has had by far the biggest return, so we've just doubled down on it over and over and over, until now we're at the point that, y…”
Zuckerberg: Physical co-location solves organizational friction better than org charts
“It's interesting how many organizational questions or problems you can fix just by having two teams sit together, right? It's like, it doesn't matter what the org chart is or like, whatever. It's like, you guys need to sit next to each other and until you get …”
Zuckerberg: GPUs are zero-sum resources, but scientific data is not
“The GPUs are somewhat zero-sum, right? So the data isn't.”
Zuckerberg: Metaverse's advantage over phones is shared physical presence
“The thing that you can do in the metaverse that is different from what you can do on a phone is like doing stuff where you're physically there together and Participating in things together, and we could play games like this.”
Zuckerberg: The first CZ Biohub united UCSF, Stanford, and UC Berkeley
“So the very first biohub, what we did, there were two kind of interesting things. One was, it was this collaboration between UCSF, Stanford, and Berkeley. And there are all these really smart people at all these different places who previously, I guess in theo…”