The Ledger

Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.

clear all ✕

why aren't all 3 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 0 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable

Insight
Tran: CRISPR is evolving into a cellular search engine platform
“Instead of just this pair of molecular scissors that everyone talks about, the biggest recent shift in the field is this push towards making CRISPR a search engine platform of the cell.”
Andy Tran Oct 5, 2019 ▶ 6:21 CRISPR 2.0 and the Future of Gene Therapies
Insight
Andy Tran: Gene therapy winners will pair platforms with disease-specific optimization
“Regardless of the type of vector that you're engineering, we believe the winners in the space are the ones that could harness a specific platform and marry it with very thoughtful optimization towards specific disease areas.”
Andy Tran Oct 5, 2019 ▶ 14:55 CRISPR 2.0 and the Future of Gene Therapies
Insight
Tran: Simple CRISPR knockouts often outperform complex new genome engineering tools
“Many times, the latest, most advanced, mechanistically complex, and by definition least validated system is not the best tool if a simple CRISPR knockout, for instance, can solve your problem.”
Andy Tran Oct 5, 2019 ▶ 23:31 CRISPR 2.0 and the Future of Gene Therapies
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