The Ledger

Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.

2statements match

2resolved → 0open claims → 2supported → 0contradicted →

why aren't all 2 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 0 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable

Assertion Supported

Interpreting novel genetic variants costs 100x to 1000x more than sequencing

“And interpreting each one of those under the current clinical practices costs 50 to a hundred dollars. So we're talking about a hundred to thousand-fold increase in the cost of interpretation relative to the cost of data acquisition.”

Carlos Araya Jan 2, 2019 ▶ 2:59 a16z Podcast | Revisiting the Gene

Assertion Supported

Only 0.6% of disease-associated gene mutations have clinical interpretations

“If we look across all of the disease-associated genes that we know today, we only have clinical interpretations for roughly . Six percent of the possible mutations in them.”

Carlos Araya Jan 2, 2019 ▶ 3:52 a16z Podcast | Revisiting the Gene

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The Ledger

Turn any episode into a week of clips.