“We're expecting at least 10 to 20 gene therapy approvals per year by the end of the decade.”
quote is from the automated transcript, cleaned for reading:
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More from Andy Tran
AssertionSupported
Andy Tran: Gene Editing Enables Curative Single-Dose Treatments
“Of course, this is certainly a big paradigm shift and very exciting as these technologies have given us the power to precisely target And eliminate the origin of disease, as well as be very curative with just a single dose of the drug.”
Andy TranOct 5, 2019▶ 1:24CRISPR 2.0 and the Future of Gene Therapies
Insight
Tran: CRISPR is evolving into a cellular search engine platform
“Instead of just this pair of molecular scissors that everyone talks about, the biggest recent shift in the field is this push towards making CRISPR a search engine platform of the cell.”
Andy TranOct 5, 2019▶ 6:21CRISPR 2.0 and the Future of Gene Therapies
Insight
Andy Tran: Gene therapy winners will pair platforms with disease-specific optimization
“Regardless of the type of vector that you're engineering, we believe the winners in the space are the ones that could harness a specific platform and marry it with very thoughtful optimization towards specific disease areas.”
Andy TranOct 5, 2019▶ 14:55CRISPR 2.0 and the Future of Gene Therapies
PredictionNot checkable as stated
Tran: Metagenomic mining will uncover genome editing systems beyond CRISPR
“As we continue to mine new metagenomic data of new species, it's not crazy to think that perhaps even CRISPR itself is by no means the final frontier of genome engineering.”
Andy TranOct 5, 2019▶ 18:46CRISPR 2.0 and the Future of Gene Therapies
Opinion
Tran: Manufacturing is an overlooked existential threat to gene therapy
“So once you've designed the perfect gene therapy, perhaps one of the most overlooked, but most existential threats to the industry is challenges in manufacturing.”
Andy TranOct 5, 2019▶ 19:23CRISPR 2.0 and the Future of Gene Therapies
Insight
Tran: Simple CRISPR knockouts often outperform complex new genome engineering tools
“Many times, the latest, most advanced, mechanistically complex, and by definition least validated system is not the best tool if a simple CRISPR knockout, for instance, can solve your problem.”
Andy TranOct 5, 2019▶ 23:31CRISPR 2.0 and the Future of Gene Therapies
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