Deleting senescent cells can boost animal lifespan by up to 30%
Kristen Fortney · Extending Human Lifespan · Dec 23, 2018 · at 5:41
BioAge CEO Kristen Fortney explains research on cellular senescence and how clearing non-functioning 'zombie' cells extends lifespan and healthspan in animal models.
0:00 / 0:04exact quote · 4.7s
▶ Watch the full episode on YouTube → 720p mp4 · rendered on demand · StarZero watermark
“If you could delete these cells, that could boost lifespan as much as 30%, ah, and healthspan as well.”
quote is from the automated transcript, cleaned for reading: filler sounds and stutters are removed, nothing is rephrased. names can be misheard (the analysis reads context, assessments check outside sources). how →
More from Kristen Fortney
Fortney: Near-term therapies will add 10 to 20 years to human life
“I think the near-term therapies are going to add, say, 10 to 20 years.”
Targeting aging directly could extend average human lifespan to 113 years
“That would get the average lifespan up to 113 by targeting aging directly rather than targeting individual diseases one at a time. And what's really key too is this would be an additional 30 years of healthy life.”
Current longevity clinical trials could add 10 to 20 healthy years
“Three different therapies are already in the clinic today. So as I mentioned, there are drugs targeting senescence, metformin, and there are drugs targeting rapamycin being tested in clinical trials now. And I think that could already add 10 to 20 years of hea…”
Kristen Fortney argues there is no hard biological limit on lifespan
“Going forward in the future, I think it's a really important point to mention that there is no hard biological limit on how long we can live, and these are a couple really fascinating examples. Bowhead whales, their average lifespan is over 200 years, so they'…”
Fortney: Clearing senescent cells in mice boosted lifespan by 30 percent
“And they showed that if you killed senescent cells in a mouse, you could boost lifespan by 30%.”
Fortney: NIA tested 30 lifespan drugs compared to 110,000 for cancer
“The National Cancer Institute, the total number of drugs they've given to mice to see if they cure mouse cancer is over a 110,000. The number of drugs that the National Institute on Aging has given to mice to see if they live longer is 30.”