Aug 7, 2017 · 31m · 20vc

20VC: Why We Will Continue To See An Explosion In Deep Tech Financing, Why Much of Silicon Valley's Talent Is Going To Waste & How Fund Cycles Need To Be Adjusted To Work With Deep Tech with Seth Bannon, Founding Partner @ Fifty Years

Seth Bannon · 21m spoken Harry Stebbings · 8m spoken
0:00 / 0:00

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Host Harry Stebbings interviews Seth Bannon, founding partner of 50 Years, about why purpose-driven deep tech startups are outperforming traditional software models and how venture capital must adapt to support them.

How this conversation actually went

Every chapter scored 0–10 on four independent dynamics. Hover any point for the reasoning behind the score. Harry holds 29.2% of the talking time here. How this is scored →

Harry as informed peer 5.0 Guest teaching 4.4 Guest disagreement 2.1 Harry pushing back 4.4
05100:0010:0020:0030:002:27–6:21 · Harry as informed peer 2/10 Seth Bannon's Career Background and Path to VC Harry allows Seth to walk through his career arc from political campaigning to founding 50 Years with minimal intervention. Harry asks conversational questions while Seth delivers a fluent narrative about bridging the gap between impact and tech VC.6:26–9:08 · Harry as informed peer 5/10 Challenging the Friedman Doctrine Harry pushes back on Seth's critique of the Friedman Doctrine by questioning whether true profit maximization can coexist with a social impact mandate. Seth educates the host using the analogy of cloud adoption as a core strategic advantage.9:13–12:30 · Harry as informed peer 5/10 Millennial Values as Catalysts for Purpose-Driven Business Harry challenges Seth on whether growing consumer awareness makes brand the primary defensible IP over technology. Seth reframes the debate around talent acquisition and retention, citing statistics on millennial employee turnover.12:43–15:11 · Harry as informed peer 5/10 Integrating Impact Directly into the Profit Model Harry asks Seth to outline the drawbacks of impact investing and how impact is tied to financial metrics. Seth responds by strongly rejecting superficial 'one-for-one' donation models in favor of tightly aligned unit economics where revenue directly equals impact.15:17–18:09 · Harry as informed peer 6/10 Why Deep Tech Financing Is Exploding Harry presses Seth on the extended timelines and heavy capital needs of deep tech startups compared to standard software deals. Seth explains how falling underlying costs in synthetic biology and non-dilutive debt financing alter the risk profile.18:11–22:54 · Harry as informed peer 7/10 Deep Tech Growth Capital, Exits, and Fund Cycles Harry demonstrates strong VC expertise by challenging Seth on structural deep tech issues, including early incumbent acquisitions and 10-year fund life limitations. Harry refuses to accept Seth's initial answer on founder ambition, pressing on why founders accept early $20M buyouts.22:55–29:47 · Harry as informed peer 5/10 Conducting Technical Diligence in Deep Tech Harry asks how a generalist fund scales up on deep technical topics like synthetic biology, prompting Seth to outline his diligence network of PhDs and peer founders. Harry then guides a lively quickfire round on investment principles and Silicon Valley dynamics.2:27–6:21 · Guest teaching 2/10 Seth Bannon's Career Background and Path to VC Harry allows Seth to walk through his career arc from political campaigning to founding 50 Years with minimal intervention. Harry asks conversational questions while Seth delivers a fluent narrative about bridging the gap between impact and tech VC.6:26–9:08 · Guest teaching 5/10 Challenging the Friedman Doctrine Harry pushes back on Seth's critique of the Friedman Doctrine by questioning whether true profit maximization can coexist with a social impact mandate. Seth educates the host using the analogy of cloud adoption as a core strategic advantage.9:13–12:30 · Guest teaching 5/10 Millennial Values as Catalysts for Purpose-Driven Business Harry challenges Seth on whether growing consumer awareness makes brand the primary defensible IP over technology. Seth reframes the debate around talent acquisition and retention, citing statistics on millennial employee turnover.12:43–15:11 · Guest teaching 5/10 Integrating Impact Directly into the Profit Model Harry asks Seth to outline the drawbacks of impact investing and how impact is tied to financial metrics. Seth responds by strongly rejecting superficial 'one-for-one' donation models in favor of tightly aligned unit economics where revenue directly equals impact.15:17–18:09 · Guest teaching 5/10 Why Deep Tech Financing Is Exploding Harry presses Seth on the extended timelines and heavy capital needs of deep tech startups compared to standard software deals. Seth explains how falling underlying costs in synthetic biology and non-dilutive debt financing alter the risk profile.18:11–22:54 · Guest teaching 5/10 Deep Tech Growth Capital, Exits, and Fund Cycles Harry demonstrates strong VC expertise by challenging Seth on structural deep tech issues, including early incumbent acquisitions and 10-year fund life limitations. Harry refuses to accept Seth's initial answer on founder ambition, pressing on why founders accept early $20M buyouts.22:55–29:47 · Guest teaching 4/10 Conducting Technical Diligence in Deep Tech Harry asks how a generalist fund scales up on deep technical topics like synthetic biology, prompting Seth to outline his diligence network of PhDs and peer founders. Harry then guides a lively quickfire round on investment principles and Silicon Valley dynamics.2:27–6:21 · Guest disagreement 1/10 Seth Bannon's Career Background and Path to VC Harry allows Seth to walk through his career arc from political campaigning to founding 50 Years with minimal intervention. Harry asks conversational questions while Seth delivers a fluent narrative about bridging the gap between impact and tech VC.6:26–9:08 · Guest disagreement 2/10 Challenging the Friedman Doctrine Harry pushes back on Seth's critique of the Friedman Doctrine by questioning whether true profit maximization can coexist with a social impact mandate. Seth educates the host using the analogy of cloud adoption as a core strategic advantage.9:13–12:30 · Guest disagreement 2/10 Millennial Values as Catalysts for Purpose-Driven Business Harry challenges Seth on whether growing consumer awareness makes brand the primary defensible IP over technology. Seth reframes the debate around talent acquisition and retention, citing statistics on millennial employee turnover.12:43–15:11 · Guest disagreement 3/10 Integrating Impact Directly into the Profit Model Harry asks Seth to outline the drawbacks of impact investing and how impact is tied to financial metrics. Seth responds by strongly rejecting superficial 'one-for-one' donation models in favor of tightly aligned unit economics where revenue directly equals impact.15:17–18:09 · Guest disagreement 2/10 Why Deep Tech Financing Is Exploding Harry presses Seth on the extended timelines and heavy capital needs of deep tech startups compared to standard software deals. Seth explains how falling underlying costs in synthetic biology and non-dilutive debt financing alter the risk profile.18:11–22:54 · Guest disagreement 3/10 Deep Tech Growth Capital, Exits, and Fund Cycles Harry demonstrates strong VC expertise by challenging Seth on structural deep tech issues, including early incumbent acquisitions and 10-year fund life limitations. Harry refuses to accept Seth's initial answer on founder ambition, pressing on why founders accept early $20M buyouts.22:55–29:47 · Guest disagreement 2/10 Conducting Technical Diligence in Deep Tech Harry asks how a generalist fund scales up on deep technical topics like synthetic biology, prompting Seth to outline his diligence network of PhDs and peer founders. Harry then guides a lively quickfire round on investment principles and Silicon Valley dynamics.2:27–6:21 · Harry pushing back 1/10 Seth Bannon's Career Background and Path to VC Harry allows Seth to walk through his career arc from political campaigning to founding 50 Years with minimal intervention. Harry asks conversational questions while Seth delivers a fluent narrative about bridging the gap between impact and tech VC.6:26–9:08 · Harry pushing back 5/10 Challenging the Friedman Doctrine Harry pushes back on Seth's critique of the Friedman Doctrine by questioning whether true profit maximization can coexist with a social impact mandate. Seth educates the host using the analogy of cloud adoption as a core strategic advantage.9:13–12:30 · Harry pushing back 4/10 Millennial Values as Catalysts for Purpose-Driven Business Harry challenges Seth on whether growing consumer awareness makes brand the primary defensible IP over technology. Seth reframes the debate around talent acquisition and retention, citing statistics on millennial employee turnover.12:43–15:11 · Harry pushing back 5/10 Integrating Impact Directly into the Profit Model Harry asks Seth to outline the drawbacks of impact investing and how impact is tied to financial metrics. Seth responds by strongly rejecting superficial 'one-for-one' donation models in favor of tightly aligned unit economics where revenue directly equals impact.15:17–18:09 · Harry pushing back 6/10 Why Deep Tech Financing Is Exploding Harry presses Seth on the extended timelines and heavy capital needs of deep tech startups compared to standard software deals. Seth explains how falling underlying costs in synthetic biology and non-dilutive debt financing alter the risk profile.18:11–22:54 · Harry pushing back 7/10 Deep Tech Growth Capital, Exits, and Fund Cycles Harry demonstrates strong VC expertise by challenging Seth on structural deep tech issues, including early incumbent acquisitions and 10-year fund life limitations. Harry refuses to accept Seth's initial answer on founder ambition, pressing on why founders accept early $20M buyouts.22:55–29:47 · Harry pushing back 3/10 Conducting Technical Diligence in Deep Tech Harry asks how a generalist fund scales up on deep technical topics like synthetic biology, prompting Seth to outline his diligence network of PhDs and peer founders. Harry then guides a lively quickfire round on investment principles and Silicon Valley dynamics.

speaking balance: gold is Harry, purple is the guest (3 minute bins)

0:00 · Harry 95.6% · guest 4.4%0:00 · Harry 95.6% · guest 4.4%3:00 · Harry 0.8% · guest 99.2%3:00 · Harry 0.8% · guest 99.2%6:00 · Harry 14.8% · guest 85.2%6:00 · Harry 14.8% · guest 85.2%9:00 · Harry 10.1% · guest 89.9%9:00 · Harry 10.1% · guest 89.9%12:00 · Harry 18.7% · guest 81.3%12:00 · Harry 18.7% · guest 81.3%15:00 · Harry 22.7% · guest 77.3%15:00 · Harry 22.7% · guest 77.3%18:00 · Harry 32.4% · guest 67.6%18:00 · Harry 32.4% · guest 67.6%21:00 · Harry 15.7% · guest 84.3%21:00 · Harry 15.7% · guest 84.3%24:00 · Harry 19.2% · guest 80.8%24:00 · Harry 19.2% · guest 80.8%27:00 · Harry 16.6% · guest 83.4%27:00 · Harry 16.6% · guest 83.4%30:00 · Harry 100% · guest 0%30:00 · Harry 100% · guest 0%
Sharpest disagreement ▶ 14:31 Rejection of 1-for-1 donation models

Seth forcefully dismisses 'one for one' impact models like Toms shoes, arguing that defensible impact requires a business model where every unit of revenue inherently produces positive impact.

Hardest push from Harry ▶ 20:29 Challenging founder promises against early buyouts

Harry refuses to accept Seth's optimistic view on founder persistence, pointing out that many founders promise to build billion-dollar companies but fold as soon as a $20 million offer arrives.

Biggest teaching moment ▶ 10:25 Reframing IP as talent acquisition advantage

Seth educates Harry by explaining that the true competitive advantage of mission-aligned companies is not consumer brand IP, but rather their ability to attract and retain elite millennial technical talent.

Harry holds his own ▶ 21:41 Highlighting 10-year fund cycle friction with deep tech

Harry displays precise venture capital domain knowledge by challenging whether traditional 10-year fund cycles are structurally flawed for supporting deep tech investments.

the scores for every segment, with the reasoning behind each
ChapterTopicHarry as informed peerGuest teachingGuest disagreementHarry pushing backWhy
Seth Bannon's Career Background and Path to VC 2211 Harry allows Seth to walk through his career arc from political campaigning to founding 50 Years with minimal intervention. Harry asks conversational questions while Seth delivers a fluent narrative about bridging the gap between impact and tech VC.
Challenging the Friedman Doctrine 5525 Harry pushes back on Seth's critique of the Friedman Doctrine by questioning whether true profit maximization can coexist with a social impact mandate. Seth educates the host using the analogy of cloud adoption as a core strategic advantage.
Millennial Values as Catalysts for Purpose-Driven Business 5524 Harry challenges Seth on whether growing consumer awareness makes brand the primary defensible IP over technology. Seth reframes the debate around talent acquisition and retention, citing statistics on millennial employee turnover.
Integrating Impact Directly into the Profit Model 5535 Harry asks Seth to outline the drawbacks of impact investing and how impact is tied to financial metrics. Seth responds by strongly rejecting superficial 'one-for-one' donation models in favor of tightly aligned unit economics where revenue directly equals impact.
Why Deep Tech Financing Is Exploding 6526 Harry presses Seth on the extended timelines and heavy capital needs of deep tech startups compared to standard software deals. Seth explains how falling underlying costs in synthetic biology and non-dilutive debt financing alter the risk profile.
Deep Tech Growth Capital, Exits, and Fund Cycles 7537 Harry demonstrates strong VC expertise by challenging Seth on structural deep tech issues, including early incumbent acquisitions and 10-year fund life limitations. Harry refuses to accept Seth's initial answer on founder ambition, pressing on why founders accept early $20M buyouts.
Conducting Technical Diligence in Deep Tech 5423 Harry asks how a generalist fund scales up on deep technical topics like synthetic biology, prompting Seth to outline his diligence network of PhDs and peer founders. Harry then guides a lively quickfire round on investment principles and Silicon Valley dynamics.

Statements from this episode (15)

Opinion
Bannon: Impact investors lack tech skills, tech VCs only care about profits
“When we talked to investors, we found that they all basically fell into one of two buckets. Either you had the people who really cared about the why, or, you know, what are traditionally called impact investors, but who knew basically nothing about technology …”
Seth Bannon Aug 7, 2017 ▶ 5:29
Opinion
Bannon: The Friedman Doctrine is one of history's most dangerous economic ideas
“We think it's actually one of the most wrongheaded and probably dangerous doctrines in the history of the world, and I know it sounds a little Strange to say that an economic doctrine is very dangerous, but we think it's allowed a lot of businesses to pursue p…”
Seth Bannon Aug 7, 2017 ▶ 7:41
Insight
Bannon: Solving societal problems gives startups a systemic competitive advantage
“I believe you can. And so, we get this question a lot, and one of, I think, the analogies that I like to give is, at some point, people thought the transition to the cloud was going to be a really big deal, and that cloud-based companies would have very real a…”
Seth Bannon Aug 7, 2017 ▶ 8:29
Assertion Supported
Bannon: 87% of millennials measure business success beyond financial performance
“Deloitte, for example, did a study of 7700 millennials across 29 countries. And 87% of the millennials they surveyed said that the success of a business should be measured in terms of more than just its financial performance.”
Seth Bannon Aug 7, 2017 ▶ 9:49
Assertion Supported
Bannon: 83% of MBAs would take a pay cut for societal impact
“Net Impact did a study of MBA students and found that 83% would take a 15% pay cut to work for a company that had positive societal or environmental ends.”
Seth Bannon Aug 7, 2017 ▶ 11:42
Prediction Not checkable as stated
Bannon: Fifty Years requires a clear path to $1B in revenue
“Our sort of like very high level filters are we want founders that are interested in building billion dollar businesses that have positive impact. Then we want to see ourselves a path to a billion dollars in revenue. And then we want to see ourselves the path …”
Seth Bannon Aug 7, 2017 ▶ 13:48
Opinion
Bannon: One-for-one impact models like Toms Shoes are inherently flawed
“We really don't like the sort of like one for one model companies. Right. So like the Tom's shoe or like for every shoe we sell, we're going to donate shoes to a country in the third world because then the good you're doing always has to be defended. When you'…”
Seth Bannon Aug 7, 2017 ▶ 14:36
Assertion Not checkable as stated
Bannon: Synthetic biology seed costs now match standard SaaS seed budgets
“There have been a number of changes over the last five years that actually allow you to get from idea to prototype product on the same amount of money you would need to raise for a seed round if you're raising for a SaaS company, right?”
Seth Bannon Aug 7, 2017 ▶ 16:12
Disclosure
Bannon: Deep tech startups should shift to debt after three equity rounds
“So almost every single deep tech company that we've invested in has a clear path to growing off of equity for maybe three rounds, and then growing off of project or debt financing for the rest of their life.”
Seth Bannon Aug 7, 2017 ▶ 17:59
Assertion Supported
Bannon: Y Combinator has heavily shifted focus to biotech since 2013
“Even if you look at something early stage like Y Combinator, right, they have invested way more attention and resources into attracting and helping synthetic biology and biotech companies than they did four years ago. Four years ago, they weren't doing it at a…”
Seth Bannon Aug 7, 2017 ▶ 18:53
Insight
Bannon: A 15-20 year fund lifecycle is VC's biggest opportunity
“I think the biggest opportunity in investing right now might just be a fund that has a 15 to twenty-year life cycle.”
Seth Bannon Aug 7, 2017 ▶ 21:55
Opinion
Bannon: Mission-driven funds get more technical diligence help than traditional VCs
“Given our fund's mission, people are willing to help us do that more so than they would be with a traditional fund.”
Seth Bannon Aug 7, 2017 ▶ 24:43
Prediction Open · timeframe Aug 2117
Bannon: Animal agriculture will be completely eliminated within 100 years
“I believe that animal agriculture will be eliminated from the face of the earth within the next hundred years.”
Seth Bannon Aug 7, 2017 ▶ 26:59
Opinion
Bannon: Silicon Valley talent is largely wasted on trivial tech problems
“I think there's just such incredible talent in Silicon Valley, and I think it is largely going to waste. I think that way too many incredibly talented people are working on incredibly trivial things, and I see it around me a lot where people are going through …”
Seth Bannon Aug 7, 2017 ▶ 27:37
Assertion Partly supported
Bannon: Othellis blood diagnostic hardware costs $250 and $5 per test
“The Ethelus device cost 250 bucks, and each test Costs five dollars, and it gives you results in minutes, and it works.”
Seth Bannon Aug 7, 2017 ▶ 29:06
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